Abstract Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease prognosis.PLK1 has been shown to interact with NUMB, a NOTCH antagonist.However, the exact role of PLK1, NUMB, and NOTCH signaling in epithelial-mesenchymal transition (EMT) in melanoma progression is
Collapsing towards Extinction? Trade in Birds Carcasses for Traditional Medicine and the Decline of Vulture Population in Katsina State, Nigeria
Decline in vulture populations have seriously reported in Nigeria as in other habits around the world.Human pressure from poisoning, hunting and trading for traditional medicine are key factors leading to decline of vulture population in northern Nigeria.This study examines vulture trading for traditional medicine as risk factor for the raptors pop
Assessment of Inheritance and Fitness Costs Associated with Field-Evolved Resistance to Cry3Bb1 Maize by Western Corn Rootworm
The western corn rootworm, Diabrotica virgifera virgifera LeConte, is among the most serious insect pests of maize in North America.One strategy used to manage this pest is transgenic maize that produces one or more crystalline (Cry) toxins derived from the bacterium Bacillus thuringiensis (Bt).To delay Bt resistance by insect pests, refuges of non
Chromosome-level genome of Thymus mandschuricus reveals molecular mechanism of aroma compounds biosynthesis
BackgroundThymus mandschuricus is an aromatic and medicinal plant with notable antibacterial and antioxidant properties.However, traditional breeding methods rely on phenotypic selection due to a lack of molecular resources.A high-quality reference genome is crucial for marker-assisted breeding, genome editing, and molecular genetics.ResultsWe here